Natural Extract 98% Kavain 3155-48-4 Manufacturer CAS NO.3155-48-4

Kavain is an active ingredient extracted from kava root. Previous studies have shown that Kavain has a non-specific myotropic effect on smooth muscle membranes. The effect of Kavain in relaxing airway smooth muscle may be by inhibiting M3 receptors and calcium channels, reducing Ca2+ influx produced.
Application
Kavain is an active ingredient extracted from the root of kava pepper with anti-inflammatory and antioxidant properties. Kavain and its derivatives are currently used to treat neurological disorders, as relaxants, sedatives and anxiolytics. Application of Kavain in the preparation of drugs for the treatment of osteoporosis. Kavain inhibited osteoclasts and bone resorption by inhibiting calcium-mediated NFATc1 and MAPK signaling pathways, and Kavain treatment was also found to alleviate bone loss in OVX mice. It is well known that M-CSF and RANKL are the main cytokines that initiate osteoclast differentiation and stimulate their bone resorption function. NFATc1, a master transcription factor promoting osteoclast differentiation, is induced upon activation of the RANKL/RANK axis.
Kavain inhibited osteoclast formation and function by modulating intracellular calcium-mediated inactivation of NFATc1 and MAPK, but not osteoblasts (Figure 7). In addition, Kavain can also inhibit ovariectomy-induced osteoporosis by inhibiting osteoclastogenesis. This natural compound has a potential role in the treatment of osteolytic diseases.
The main role in cosmetics and skin care products is skin conditioning agent. The risk factor is relatively safe and can be used with confidence. Generally, it has no effect on pregnant women. Kava extract is not acne-causing.
Kavain has sedative, hypnotic, antibacterial, analgesic and other pharmacological effects, and is widely used in nutritional supplements and herbal preparations in Europe and the United States. Kava pepper extract, mainly containing kavalactone, kavapyrone and so on. Specifically, 6 kinds of kava piperines: namely Kavain, dihydro Kavain, buckwheat, dihydro buckwheat, methoxy buckwheat, and demethoxy buckwheat. In cosmetics, Kavain is used for conditioning, sterilization and soothing functions.

Large stock High purity Anti-inflammatory Pharmaceutical cosmetic 40% 98% Kavain CAS 3155-48-4 Producer

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Plant extracts

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